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HUBUNGAN ANTARA EKSPRESI BRCA1 DAN GRADE SEL KANKER PADA PASIEN INVASIVE BREAST CARCINOMA DI NTB

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ABSTRAK
HUBUNGAN ANTARA EKSPRESI BRCA1 DAN GRADE SEL KANKER
PADA PASIEN INVASIVE BREAST CARCINOMA DI NTB
Romy Healthy Mikailla, Novrita Padauleng, Lale Maulin Prihatina
Latar belakang: Kanker payudara merupakan keganasan dengan insidensi tertinggi
pada perempuan di Nusa Tenggara Barat (NTB). Gen Breast Cancer 1 (BRCA1)
adalah gen supresor tumor yang berperan krusial dalam perbaikan DNA dan
stabilitas genom. Penurunan ekspresi BRCA1 secara teoritis berhubungan dengan
karakteristik tumor yang lebih agresif, seperti grade yang rendah (grade tinggi).
Namun, data mengenai hubungan antara ekspresi protein BRCA1 dan grade sel
kanker pada populasi pasien di NTB masih terbatas.
Metode: Penelitian ini menggunakan desain cross-sectional dengan pendekatan
observasional analitik pada 50 sampel blok parafin pasien Invasive Breast
Carcinoma dari RSUD Provinsi NTB periode 2022-2023. Ekspresi protein BRCA1
dinilai menggunakan metode imunohistokimia dengan cut-off positif jika
pewarnaan terdeteksi pada >20% inti sel tumor. Data grade (Grade 1, 2, dan 3)
diperoleh dari rekam medis. Analisis hubungan antara kedua variabel dilakukan
menggunakan uji Lambda, Pearson?s R, dan Spearman Correlation dengan tingkat
signifikansi p < 0,05.
Hasil: Mayoritas sampel (84%) merupakan tumor dengan grade 3. Distribusi
ekspresi BRCA1 pada total sampel seimbang, dengan 25 kasus (50%) menunjukkan
ekspresi positif dan 25 kasus (50%) menunjukkan ekspresi negatif. Pada kelompok
grade 3, distribusi ini juga tetap seimbang. Hasil analisis statistik secara konsisten
tidak menunjukkan adanya hubungan yang signifikan antara ekspresi BRCA1
dengan grade sel kanker (p > 0,05).
Simpulan: Tidak terdapat hubungan yang signifikan secara statistik antara ekspresi
protein BRCA1 dengan grade sel kanker pada pasien invasive breast carcinoma di
NTB.
Kata kunci: BRCA1, Grade, Invasive Breast Carcinoma, NTB.vii
ABSTRACT
THE RELATIONSHIP BETWEEN BRCA1 EXPRESSION AND GRADE IN
BREAST CANCER PATIENTS IN NTB
Romy Healthy Mikailla, Novrita Padauleng, Lale Maulin Prihatina
Background: Breast cancer is the malignancy with the highest incidence among
women in West Nusa Tenggara (NTB). The Breast Cancer 1 (BRCA1) gene is a
tumor suppressor gene that plays a crucial role in DNA repair and genome stability.
A decrease in BRCA1 expression is theoretically associated with more aggressive
tumor characteristics, such as a low degree of differentiation (high grade).
However, data regarding the relationship between BRCA1 protein expression and
the degree of cell differentiation in the patient population in NTB remains limited.
Methods: This study employed a cross-sectional design with an observational
analytic approach on 50 paraffin block samples from Invasive Breast Carcinoma
patients at the NTB Provincial General Hospital from 2022-2023. BRCA1 protein
expression was assessed using immunohistochemistry with a positive cut-off
defined as staining in >20% of tumor cell nuclei. Data on the degree of
differentiation (Grade 1, 2, and 3) were obtained from medical records. The
relationship between the two variables was analyzed using the Lambda, Pearson?s
R, and Spearman Correlation tests with a significance level of p < 0.05.
Results: The majority of samples (84%) were grade 3 tumors. The distribution of
BRCA1 expression in the total sample was balanced, with 25 cases (50%) showing
positive expression and 25 cases (50%) showing negative expression. In the grade
3 subgroup, this distribution remained balanced. Statistical analysis consistently
showed no significant relationship between BRCA1 expression and the degree of
cell differentiation (p > 0.05).
Conclusion: There is no statistically significant relationship between BRCA1
protein expression and the degree of cell differentiation in breast cancer patients in
NTB.
Keywords: BRCA1, Grade, Invasive Breast Carcinoma, NTB.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1369

Penerbit

Mataram : FKIK Unram., 2026

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

DTS 610 Rom h 2026

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KTI 2026

Info Detail Spesifik

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Pernyataan Tanggungjawab

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