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HUBUNGAN KADAR LOW-DENSITY LIPOPROTEIN DAN CAROTID INTIMA-MEDIA THICKNESS PADA PASIEN PENYAKIT GINJAL KRONIS YANG MENJALANI HEMODIALISIS DI RSUD PROVINSI NTB

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ABSTRAK
HUBUNGAN KADAR LOW-DENSITY LIPOPROTEIN DAN CAROTID
INTIMA-MEDIA THICKNESS PADA PASIEN PENYAKIT GINJAL
KRONIS YANG MENJALANI HEMODIALISIS DI RSUD PROVINSI NTB
Firdaus Kamma Patandianan, Yanna Indrayana, Romi Ermawan
Latar belakang: Penyakit ginjal kronis (PGK) merupakan masalah kesehatan
global dengan prevalensi yang terus meningkat dan berkontribusi signifikan
terhadap morbiditas serta mortalitas, terutama akibat komplikasi kardiovaskular.
Pasien PGK yang menjalani hemodialisis memiliki risiko aterosklerosis yang lebih
tinggi akibat kombinasi faktor tradisional dan nontradisional, termasuk gangguan
metabolisme lipid. Low-density lipoprotein (LDL) berperan penting dalam proses
aterogenesis. Carotid intima-media thickness (CIMT) merupakan metode noninvasif yang banyak digunakan sebagai penanda dini aterosklerosis subklinis dan
prediktor penyakit kardiovaskular. Hubungan kadar LDL dan CIMT pada pasien
PGK yang menjalani hemodialisis di Indonesia masih terbatas, khususnya di
Provinsi Nusa Tenggara Barat. Oleh karena itu, penelitian ini dilakukan untuk
menganalisis hubungan antara kadar LDL dan CIMT pada pasien PGK yang
menjalani hemodialisis di RSUD Provinsi NTB.
Metode: Penelitian ini merupakan penelitian observasional analitik dengan
rancangan cross-sectional yang dilakukan di RSUD Provinsi NTB. Pasien PGK
yang menjalani hemodialisis dan memenuhi kriteria penelitian diikutsertakan. Data
yang dikumpulkan meliputi kadar profil lipid termasuk LDL, pengukuran CIMT
dengan ultrasonografi B-mode, serta karakteristik demografis dan klinis.
Pengolahan dan analisis statistik menggunakan uji korelasi Spearman dan MannWhitney U.
Hasil: Sebanyak 62 pasien diikutsertakan (40 laki-laki, 22 perempuan; usia rata rata
50,87 ? 12,15 tahun). Median CIMT pasien adalah 0,70 mm (0,64 ? 0,77) dan kadar
LDL 0,70 mg/dL (0,64 ? 0,77). LDL tidak memiliki korelasi yang signifikan dengan
CIMT pada seluruh pasien (r = 0, 179; p = 0,165).
Kesimpulan: Tidak terdapat hubungan yang bermakna antara kadar low-density
lipoprotein dan carotid intima-media thickness pada pasien penyakit ginjal kronis
yang menjalani hemodialisis di RSUD Provinsi NTB.
Kata kunci: penyakit ginjal kronis, hemodialisis, lipoprotein densitas rendah,
ketebalan intima-media arteri karotisvii
ABSTRACT
CORRELATION OF LOW-DENSITY LIPOPROTEIN LEVELS AND
CAROTID INTIMA-MEDIA THICKNESS IN PATIENT WITH CHRONIC
KIDNEY DISEASE ON HEMODIALYSIS AT THE PROVINCIAL
GENERAL HOSPITAL OF WEST NUSA TENGGARA
Firdaus Kamma Patandianan, Yanna Indrayana, Romi Ermawan
Background: Chronic kidney disease (CKD) is a global health problem with a
continuously increasing prevalence and contributes significantly to morbidity and
mortality, particularly due to cardiovascular complications. Patients with CKD on
hemodialysis have a higher risk of atherosclerosis as a result of both traditional and
non-traditional risk factors, including disorders of lipid metabolism. Low-density
lipoprotein (LDL) plays an important role in the process of atherogenesis. Carotid
intima?media thickness (CIMT) is a non-invasive method widely used as an early
marker of subclinical atherosclerosis and a predictor of cardiovascular disease.
However, data regarding the relationship between LDL levels and CIMT in patients
with CKD on hemodialysis in Indonesia remain limited, particularly in West Nusa
Tenggara Province. Therefore, this study aims to analyze the relationship between
LDL levels and CIMT in patients with CKD on hemodialysis at the Provincial
General Hospital of West Nusa Tenggara.
Method: This study was an analytic observational study with a cross-sectional
design conducted at the Provincial General Hospital of West Nusa Tenggara.
Patients with chronic kidney disease on hemodialysis who met the study criteria
were included. Data collected included lipid profile levels, including LDL, CIMT
measurements using B-mode ultrasonography, as well as demographic and clinical
characteristics. Data processing and statistical analysis were performed using the
Spearman correlation test and the Mann?Whitney U test.
Result: A total of 62 patients were included (40 males and 22 females; mean age
50.87 ? 12.15 years). The median CIMT was 0.70 mm (0.64?0.77), and the median
LDL level was 0.70 mg/dL (0.64?0.77). LDL levels showed no significant
correlation with CIMT in the overall study population (r = 0.179; p = 0.165).
Conclusion: There was no significant relationship between low-density lipoprotein
levels and carotid intima?media thickness in patients with chronic kidney disease
on hemodialysis at the Provincial General Hospital of West Nusa Tenggara.
Keyword: Chronic kidney disease, Hemodialysis, Low-density lipoprotein,
Carotid intima-media thickness

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1390

Penerbit

Mataram : FKIK Unram., 2026

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

DTS 610 Fir h 2026

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KTI 2026

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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