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KORELASI KADAR PROTEIN NRF2 TERHADAP FUNGSI KOGNITIF DOMAIN FUNGSI EKSEKUTIF PADA MASYARAKAT PESISIR PULAU LOMBOK

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ABSTRAK
KORELASI KADAR PROTEIN NRF2 TERHADAP FUNGSI KOGNITIF
DOMAIN FUNGSI EKSEKUTIF PADA MASYARAKAT PESISIR PULAU
LOMBOK
Inayah Wulandari, Nurhidayati, Ilsa Hunaifi
Latar Belakang: Gangguan kognitif merupakan gangguan neurodegeneratif yang
dapat menyebabkan terjadinya penurunan memori, penilaian, bahasa, perhatian dan
fungsi eksekutif yang akan mempengaruhi produktivitas yang sering dialami oleh
lansia. Disregulasi homeostasis redoks memiliki peranan penting dalam penyakit
neurodegeneratif. Nuclease factor (erythroid-derived 2)-like 2 (NRF2) adalah
faktor transkripsi sensitif redoks yang berperan penting dalam mekanisme pertahan
sel terhadap ROS yang menginduksi ekspresi gen sitoprotektif.
Metode: Metode penelitian yang digunakan adalah cross sectional. Pengambilan
sampel dilakukan dengan teknik consecutive sampling. Pemeriksaan kadar NRF2
serum sampel diukur dengan ELISA menggunakan sampel darah. Karakteristik
sosiodemografi (usia, jenis kelamin, dan tingkat Pendidikan), hipertensi, diabetes,
merokok, dan aktivitas fisik juga dikumpulkan. Fungsi ekskutif dinilai
menggunakan Clock Drawing Test (CDT). Korelasi kadar NRF2 serum dan fungsi
esksekutif di uji menggunakan uji korelasi spearman.
Hasil: Jumlah sampel penelitian yaitu sebanyak 39 sampel dengan rerata berusia
53,38 tahun, jenis kelamin perempuan, pendidikan rendah, tidak hipertensi, tidak
diabetes, aktivitas fisik tinggi, dan tidak merokok. Rerata kadar NRF2 0,54 ng/mL
dan skor CDT yaitu 1,83. Hasil uji korelasi menunjukkan tidak terdapat korelasi
yang bermakna antara kadar NRF2 serum dengan fungsi eksekutif (p=0,160).
Kesimpulan: Kadar NRF2 serum tidak berkorelasi dengan gangguan fungsi
eksekutif
Kata Kunci: Fungsi kognitif, fungsi eksekutif, NRF2v
ABSTRACT
CORRELATION OF NRF2 PROTEIN LEVELS WITH COGNITIVE
FUNCTION OF EXECUTIVE FUNCTION DOMAIN IN COASTAL
COMMUNITIES OF LOMBOK ISLAND
Inayah Wulandari, Nurhidayati, Ilsa Hunaifi
Background: Cognitive impairment is a neurodegenerative disorder that causes a
decline in memory, judgment, language, attention, and executive function, which is
often experienced by the elderly. Dysregulation of redox homeostasis plays an
important role in neurodegenerative diseases. Nuclear factor (erythroid-derived 2)-
like 2 (NRF2) is a redox-sensitive transcription factor that plays a crucial role in the
cellular defense mechanisms against ROS by inducing the expression of
cytoprotective genes.
Method: The research method used was cross-sectional. The sampling was
conducted using the consecutive sampling. The serum NRF2 levels of the samples
were measured using ELISA with blood samples. Sociodemographic characteristics
(age, gender, and education level), hypertension, diabetes, smoking, and physical
activity were also collected. Executive function was assessed using the Clock
Drawing Test (CDT). The correlation between serum NRF2 levels and executive
function was analyzed using the Spearman correlation test.
Result: The total number of samples in the study was 39, with an average age of
53.38 years, female gender, low education, no hypertension, no diabetes, high
physical activity, and non-smokers. The average NRF2 level was 0.54 ng/mL, and
CDT score was 1.83. The results of the correlation test showed that there was no
significant correlation between serum NRF2 levels and executive function
(p=0.160).
Summary: There no significant correlation between serum NRF2 levels and
executive function

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1401

Penerbit

Mataram : FKIK Unram., 2026

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

DTS 610 Ina k 2026

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KTI 2026

Info Detail Spesifik

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Pernyataan Tanggungjawab

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