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KORELASI KADAR PROTEIN NUCLEAR FACTOR ERYTHROID 2- RELATED FACTOR 2 SERUM DENGAN FUNGSI BAHASA MASYARAKAT PESISIR PULAU LOMBOK

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ABSTRAK
KORELASI KADAR PROTEIN NUCLEAR FACTOR ERYTHROID 2-RELATED
FACTOR 2 SERUM DENGAN FUNGSI BAHASA MASYARAKAT
PESISIR PULAU LOMBOK
Mishael Enoch Stephen, Nurhidayati, Herpan Syafii Harahap
Latar Belakang: Gangguan kognitif pada pasien hipertensi dapat memengaruhi
berbagai domain, termasuk fungsi bahasa. Stres oksidatif berperan penting dalam
mekanisme patogenesis gangguan kognitif melalui kerusakan sel saraf akibat
ketidakseimbangan redoks. Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)
merupakan faktor transkripsi yang berperan dalam mekanisme pertahanan sel
terhadap stres oksidatif dengan mengatur ekspresi gen antioksidan.
Metode: Penelitian ini menggunakan desain cross sectional dengan teknik
consecutive sampling. Kadar NRF2 serum diukur menggunakan ELISA dari sampel
darah. Data karakteristik sosiodemografi (usia, jenis kelamin, dan tingkat
pendidikan), derajat hipertensi, serta aktivitas fisik juga dikumpulkan. Fungsi
bahasa dinilai menggunakan Boston Naming Test (BNT) versi 15 item. Hubungan
antara kadar NRF2 serum dan fungsi bahasa dianalisis menggunakan uji korelasi
Spearman.
Hasil: Jumlah sampel penelitian yaitu sebanyak 40 sampel dengan rerata usia 53,1
tahun, jenis kelamin perempuan, menderita hipertensi, derajat aktivitas fisik tinggi,
tingkat pendidikan rendah. Hasil uji korelasi menunjukkan tidak terdapat korelasi
yang bermakna antara kadar NRF2 serum dengan fungsi bahasa (p=0,752).
Kesimpulan: Kadar protein NRF2 serum tidak berkorelasi dengan gangguan
kognitif domain bahasa.
Kata Kunci: Fungsi Kognitif, domain bahasa, NRF2vii
ABSTRACT
CORRELATION BETWEEN SERUM NUCLEAR FACTOR ERYTHROID 2?
RELATED FACTOR 2 (NRF2) LEVELS AND LANGUAGE FUNCTION IN
COASTAL COMMUNITIES OF LOMBOK ISLAND
Mishael Enoch Stephen, Nurhidayati, Herpan Syafii Harahap
Background: Cognitive impairment in patients with hypertension can affect
various domains, including language function. Oxidative stress plays an important
role in the pathogenesis of cognitive impairment through neuronal damage caused
by redox imbalance. Nuclear Factor Erythroid 2?Related Factor 2 (NRF2) is a
transcription factor involved in cellular defense mechanisms against oxidative
stress by regulating the expression of antioxidant genes.
Methods: This study used a cross-sectional design with consecutive sampling.
Serum NRF2 levels were measured using ELISA from blood samples.
Sociodemographic characteristics (age, sex, and educational level), hypertension
grade, and physical activity level were also collected. Language function was
assessed using the 15-item version of the Boston Naming Test (BNT). The
correlation between serum NRF2 levels and language function was analyzed using
Spearman?s correlation test.
Results: A total of 40 participants were included with a mean age of 53.1 years,
predominantly female, hypertensive, with high levels of physical activity and low
educational attainment. The correlation analysis showed no significant relationship
between serum NRF2 levels and language function (p = 0.752).
Conclusion: Serum NRF2 protein levels are not correlated with cognitive
impairment in the language domain.
Keywords: Cognitive function, language domain, NRF2

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

1406

Penerbit

Mataram : FKIK Unram., 2026

Deskripsi Fisik

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Bahasa

Indonesia

ISBN/ISSN

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Klasifikasi

DTS 610 Mis k 2026

Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

KTI 2026

Info Detail Spesifik

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Pernyataan Tanggungjawab

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