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FORMULASI DAN EVALUASI SEDIAAN SPRAY GEL PENYEMBUH LUKA EKSTRAK METANOL DAUN MERAH KASTUBA (Euphorbia pulcherrima Willd.)
ABSTRAK
FORMULASI DAN EVALUASI SEDIAAN SPRAY GEL PENYEMBUH
LUKA EKSTRAK METANOL DAUN MERAH KASTUBA (Euphorbia
pulcherrima Willd.)
Luka merupakan kerusakan jaringan kulit yang berisiko menimbulkan infeksi
sehingga dapat menghambat proses penyembuhan. Penggunaan sediaan topikal
dengan aktivitas antibakteri menjadi salah satu alternatif untuk mempercepat
penyembuhan luka. Daun merah kastuba (Euphorbia pulcherrima Willd.) diketahui
mengandung senyawa metabolit sekunder seperti flavonoid, fenolik, saponin, dan
steroid yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk
memformulasi dan mengevaluasi sediaan Spray Gel ekstrak metanol daun merah
kastuba serta menentukan formula terbaik. Ekstraksi dilakukan dengan metode
maserasi menggunakan pelarut metanol 96%. Sediaan diformulasikan dalam tiga
variasi basis gelling agent, yaitu HPMC, karbopol, dan kombinasi keduanya.
Evaluasi meliputi uji organoleptis, homogenitas, pH, viskositas, pola
penyemprotan, serta aktivitas antibakteri terhadap Staphylococcus aureus. Hasil
penelitian menunjukkan bahwa formula terbaik diperoleh pada formula 3 dengan
karakteristik sediaan berupa tekstur cair agak kental, warna coklat kehijauan, dan
bau aromatis, serta homogen. Nilai pH yang diperoleh sebesar 5,58, viskositas
239,16 cPs, diameter penyemprotan 5,25 cm pada jarak 20 cm, dan diameter zona
hambat iradikal sebesar 3,20 mm. Berdasarkan hasil tersebut, formula 3 sediaan
spray gel ekstrak daun merah kastuba memiliki karakteristik fisik yang paling baik
serta menunjukkan aktivitas antibakteri paling tinggi, sehingga berpotensi sebagai
alternatif sediaan topikal dalam mendukung proses penyembuhan luka.
Kata kunci: Daun merah kastuba, Euphorbia pulcherrima Willd., Spray Gel,
antibakteri, penyembuhan luka.viii
ABSTRACT
FORMULATION AND EVALUATION OF WOUND HEALING SPRAY
GEL PREPARATION FROM METHANOL EXTRACT OF RED
POINSETTIA LEAVES (Euphorbia pulcherrima Willd.)
Wounds are defined as damage to skin tissue that may lead to infection and delay
the healing process. The application of topical formulations with antibacterial
activity represents a promising approach to accelerate wound healing. Red
poinsettia leaves (Euphorbia pulcherrima Willd.) are known to contain secondary
metabolites, including flavonoids, phenolics, saponins, and steroids, which exhibit
potential antibacterial properties. This study aimed to formulate and evaluate a
Spray Gel containing methanolic extract of red poinsettia leaves and to determine
the optimal formulation. The extract was obtained through maceration using 96%
methanol as the solvent. The Spray Gel was formulated using three variations of
gelling agents, namely HPMC, carbopol, and their combination. The evaluation
parameters included organoleptic properties, homogeneity, pH, viscosity, spray
pattern, and antibacterial activity against Staphylococcus aureus. The results
showed that the best formulation was Formula 3, which had characteristics of a
slightly viscous liquid texture, greenish-brown color, aromatic odor, and
homogeneous appearance. The obtained pH value was 5.58, viscosity was 239.16
cPs, spray diameter was 5.25 cm at a distance of 20 cm, and the inhibition zone
diameter was 3.20 mm. Based on these findings, Formula 3 of the red poinsettia
leaf extract spray gel demonstrated the best physical characteristics and the highest
antibacterial activity, indicating its potential as an alternative topical preparation to
support the wound healing process.
Keywords: Red poinsettia, Euphorbia pulcherrima Willd., Spray Gel,
antibacterial, wound healing
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